一、be tired from sth 因……而疲乏，比如因做家务而累，偏重身体上的，强调造成累和疲劳是有原因的，例如：

I'm tired from doing homework.

我做作业做得很累。

I'm so tired from working out all afternoon.

运动了一整个下午，我累坏了。

Are you tired from walking all that way?

一路走来你累了吗？

I'm tired from the one job I'm doing poorly.

我已经厌倦我做不好的那份工作了。

She was tired from long studying.

她因长时间学习而感到累了。

二、be tired of sth/doing sth/sb 对……厌倦或厌烦做某事，比如厌烦某种东西某个人，或者厌烦做什么事，这个词组主要是情绪、情感上的，例如：

I'm sick and tired of all the arguments.

我对所有这些争论烦透了。

She was tired of hearing about their trip to India.

她听腻了他们的印度之行。

I'm tired of doing homework.

我讨厌做作业。

She was tired of him and wanted to leave him, perhaps to marry somebody else.

她已经厌倦了他，打算离开他，也许嫁给别的什么人。

I am tired of all the speculation.

我厌烦了所有的推测。

I was tired of being a bookkeeper.

我厌倦了当簿记员。

I'm tired of listening to all this.

这些话我都听腻了。